Tzu-chen Yeh1, Chou-Ming Cheng1, Zong-Kai Hsu2, Jen-Chuen Hsieh2, Low-Ton Ho1
1Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, Taiwan; 2Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan, Taiwan
The spatial template of default-mode network (DMN) of sixty normal subjects has been constructed as five regions of interest (ROIs) as precuneus/posterior cingulate areas with the highest reproducibility. Multimodal approaches using BOLD-based fMRI and probabilistic DTI (pDTI) demonstrated the limited structural connectivity within each ROI within DMN correlates. By penetration maps of pDTI in twenty-two normal subjects, asymmetry of bilateral cingulum cortices implied preference of right posterior medial parietal regions for interpretation of internal/external environment with concert action of medial prefrontal areas, as one of the potential functions of DMN.