Abstract #1658

Asymmetric Structural Connectivity of Default-Mode Network : An Integrated Study of FMRI and Probabilistic DTI

Tzu-chen Yeh¹, Chou-Ming Cheng¹, Zong-Kai Hsu², Jen-Chuen Hsieh², Low-Ton Ho¹

¹Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, Taiwan; ²Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan, Taiwan

The spatial template of default-mode network (DMN) of sixty normal subjects has been constructed as five regions of interest (ROIs) as precuneus/posterior cingulate areas with the highest reproducibility. Multimodal approaches using BOLD-based fMRI and probabilistic DTI (pDTI) demonstrated the limited structural connectivity within each ROI within DMN correlates. By penetration maps of pDTI in twenty-two normal subjects, asymmetry of bilateral cingulum cortices implied preference of right posterior medial parietal regions for interpretation of internal/external environment with concert action of medial prefrontal areas, as one of the potential functions of DMN.