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Abstract #1663

Assessment of the Reproducibility of HARDI Tractography Based Cortical Connectivity Measures Suitable for Clinical Populations Using a Bootstrap Approach

Kerstin Pannek1,2, Jane Mathias3, James Taylor4, Parnesh Raniga5, Olivier Salvado5, Stephen Rose1,2

1Centre for Magnetic Resonance, University of Queensland, Brisbane, Queensland, Australia; 2UQ Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia; 3School of Psychology, University of Adelaide, Adelaide, South Australia, Australia; 4Magnetic Resonance Imaging Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; 5The Australian E-Health Research Centre, CSIRO, Brisbane, Queensland, Australia

Structural connectivity of the brain using MR diffusion tractography has gained significant interest. A connectivity matrix of cortical connectivity may provide unique insight into brain organisation. We aimed to develop a method to determine the number of seeds required to obtain stable and reproducible connectivity, and to assess reproducibility over time. We employ a bootstrap approach for estimation of these parameters. While connectivity measures of some regions are highly reproducible over time, other connections show poor reproducibility. This study highlights the relationship between seed number and reproducibility of connectivity.