Abstract #1699

Diffusion Histogram as a Marker of Fiber Crossing Within a Voxel

Bryce Wilkins¹, Manbir Singh²

¹Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; ²Radiology and Biomedical Engineering, University of Southern California, Los Angeles, CA, United States

A simulation and experimental study of the histogram generated from the normalized diffusion signal measured along multiple gradient directions is presented. Voxels exhibiting an FA of at least 0.8 are identified as representative of single fiber voxels, and used to derive diffusion signals for multiple fiber crossings, in the range 0-90deg. The results illustrate how the histogram changes systematically with crossing fibers within a voxel, and suggests that the histogram can be used as a marker of the number of fibers within a voxel, and their relative orientation.