Jacob Ellegood1, Ameet S. Sengar2, M W. Salter2, S E. Egan3, Jason P. Lerch1, R M. Henkelman1
1Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; 2Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada; 3Developmental Biology, Hospital for Sick Children, Toronto, Ontario, Canada
Anatomical phenotyping in mouse has shown to be useful for determining small changes in volume. Similarly, Diffusion Tensor Imaging (DTI) of fixed mouse brain has been useful in assessing development and genetic differences in wild type and knockout mouse models. The purpose of this study was to determine both the volume and white matter structural changes in a mouse model with known white matter abnormalities. While some of the fractional anisotropy changes can be attributed to corresponding decreases in the volume, some structures and regions have changes that would go unnoticed if only volume or fractional anisotropy was measured.