Jacob Ellegood1, Ameet S. Sengar2,
M W. Salter2, S E. Egan3, Jason P. Lerch1, R
M. Henkelman1
1Mouse Imaging Centre, Hospital for
Sick Children, Toronto, Ontario, Canada; 2Neuroscience and Mental
Health, Hospital for Sick Children, Toronto, Ontario, Canada; 3Developmental
Biology, Hospital for Sick Children, Toronto, Ontario, Canada
Anatomical
phenotyping in mouse has shown to be useful for determining small changes in
volume. Similarly, Diffusion Tensor
Imaging (DTI) of fixed mouse brain has been useful in assessing development
and genetic differences in wild type and knockout mouse models. The purpose of this study was to determine
both the volume and white matter structural changes in a mouse model with
known white matter abnormalities. While
some of the fractional anisotropy changes can be attributed to corresponding
decreases in the volume, some structures and regions have changes that would
go unnoticed if only volume or fractional anisotropy was measured.