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Abstract #1705

Fractional Anisotropy Changes Following Blood Brain Barrier Disruption

Ashley D. Harris1,2, Linda B. Andersen, 2,3, Henry Chen, 2,4, Pranshu Sharma2, Richard Frayne, 2,3

1School of Psychology, CUBRIC, Cardiff University, Cardiff, United Kingdom; 2Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Alberta, Canada; 3Clinical Neurosciences and Radiology, Univerisity of Calgary, Calgary, Alberta, Canada; 4Physics, Univerisity of Calgary, Calgary, Alberta, Canada

The evolution of FA is examined in a canine model following blood brain barrier disruption with hypertonic mannitol solution. White matter and grey matter show different FA responses to blood brain barrier disruption. White matter decreases, while grey matter showed significant increases. With additional understanding, FA may assist in determining the integrity of the blood brain barrier.