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Abstract #1711

Quantitative Measurement of Cerebral Blood Flow with High Sensitivity in Mice at 9.4T

Bing Wen Zheng1, Philip Lee1, Xavier Golay1

1Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore

The aim of this study was to develop a practical and robust perfusion measurement with high sensitivity and stability in the mouse brain at high magnetic field strength, via the combination of flow-sensitive alternating inversion recovery (FAIR) and single-shot k space-banded gradient- and spin-echo (kbGRASE). To estimate the influence of physiological parameters on the precision and reproducibility of CBF measurements, changes in anesthesia regime, hypercapnia and body temperature were performed.