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Abstract #1716

MRI Measures of Cerebral Blood Flow and Cerebrovascular Reactivity in the Developing Swine Brain

Jeff D. Winter1, Stephanie Dorner2, Joseph A. Fisher3,4, Keith St. Lawrence5,6, Andrea Kassner1,7

1Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada; 2Respiratory Therapy, University Health Network, Toronto, Ontario, Canada; 3Anaesthesiology, University Health Network, Toronto, Ontario, Canada; 4Physiology, University of Toronto, Toronto, Ontario, Canada; 5Imaging Division, Lawson Health Research Institute, London, Ontario, Canada; 6Medical Biophysics, University of Western Ontario, London, Ontario, Canada; 7Medical Imaging, University of Toronto, Toronto, Ontario, Canada

The swine model is an alternative to non-human primates for neuroimaging and may be suitable for studying pediatric cerebrovascular disorders. The aim of this study was to characterize swine cerebrovascular development using BOLD cerebrovascular reactivity (CVR) and ASL cerebral blood flow (CBF). We acquired data from 13 juvenile (1-12 wk) pigs. BOLD-CVR measurements exhibited a significant logarithmic increase with body weight (Pearson r>0.81 and p<0.005 for all brain regions); whereas, baseline CBF was not related to body weight. Understanding these cerebrovascular changes will benefit future developmental studies using the swine as a translational model for cerebrovascular disease.