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Abstract #1725

Stability of Quantitative CBF Measurements Using the T1-Based DCE Approach

Otto Mlby Henriksen1, Henrik B.W. Larsson1, Adam E. Hansen1,2, Egill Rostrup1

1Functional Imaging Unit, Dept. of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, Glostrup, Denmark; 2Dept. of Radiology, Glostrup Hospital, Glostrup, Denmark

Partial volume effect (PVE) may cause erroneous determination of the arterial input function (AIF) leading to inaccurate measurements of cerebral blood flow (CBF) in bolus tracking MRI. Analyzing dynamic contrast enhanced CBF measurements in healthy subjects, we studied the effect of different PVE correction methods on 1) agreement of CBF using AIF from either the right or the left internal carotid artery 2) repeatability of repeated measurements. Scaling of the AIF to the venous output function, either by least square fit or area under the concentration curves yielded better agreement and repeatability compared to cerebral blood volume correction methods.