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Abstract #1726

A New Vascular Impulse Response Function for Modelling and Prediction with Measured Dynamic Contrast Enhanced Plasma Curves

Matthew R. Orton1, David J. Collins1, Christina Messiou1, Elly Castellano1, Jean Tessier2, Shirley Spratt3, Martin O. Leach1

1CR-UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research, Sutton, Surrey, United Kingdom; 2Early Clinical Development, AstraZeneca, Alderley Park, Macclesfield, United Kingdom; 3Clinical Discovery Team, AstraZeneca, Alderley Park, Macclesfield, United Kingdom

The blood plasma curve shape is an important component of many modelling approaches for DCE imaging, and models of these curves are used to produce functional parameter estimates. For predictions or comparisons to be made using plasma curve data obtained with different injection lengths or profiles it is necessary to include the effect of the injection profile on the plasma curve. In this abstract we present a general methodology to estimate a vascular impulse response function which is independent of the injection profile, and can therefore be used to perform such predictions and comparisons.