Meeting Banner
Abstract #1730

Blood-Brain Barrier Permeability Measured by DCE MRI Predicts Perihematomal Edema Diffusivity

Didem Bilensoy Aksoy1, Roland Bammer2, Michael Mlynash1, Sandeep N. Gupta3, Ryan W. Snider1, Irina Eyngorn1, Chitra Venkatasubramanian1, Nancy Fischbein2, Christine A.C. Wijman1

1Department of Neurology and Neurological Sciences, Stanford Stroke Center, Stanford University, Palo Alto, CA, United States; 2Department of Radiology, Stanford University, Palo Alto, CA, United States; 3Global Research Center, General Electric, Niskayuna, NY, United States

Dynamic Contrast-Enhanced (DCE) MRI was used as a tool to assess and quantify blood-brain barrier (BBB) injury following spontaneous intracerebral hemorrhage (ICH). BBB permeability and its relationship with perihematomal tissue diffusivity, a sign of edema severity, were studied. Significantly increased BBB permeability in the region immediately surrounding the hematoma was observed. BBB leakage correlated with diffusivity in the region surrounding the hematoma.