Richard Leigh1, Argye Elizabeth Hillis2, Peter B. Barker3
1Neurology, Johns Hopkins Univeristy School of Medicine, Towson, MD, United States; 2Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 3Radiology, Johns Hopkins Univeristy School of Medicine, Baltimore, MD, United States
Detection of permeability derangements in stroke patients may help guide therapy and improve outcomes. PWI, which is routinely performed in stroke imaging, can be used to assess permeability derangements through accumulation of contrast into the brain parenchyma. However it is unclear how the recorded signal can be quantified and normalized across patients. We analyzed nine stroke patients with evidence of contrast leakage on PWI to see how differences in acquisition parameters affected the recorded signal. We found that the measurements were greatly affected not only by the acquisition parameters but also the tissue type from which the signal was recorded.