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Abstract #1732

Effects of Fat Saturation on Perfusion Parameter Quantifications for the Parotid Glands in Dynamic Contrast-Enhanced MRI

Su-Chin Chiu1,2, Chun-Juan Juan2, Hsiao-Wen Chung1,2, Cheng-Chieh Cheng1,2, Hing-Chiu Chang, 1,3, Hui-Chu Chiu4,5, Cheng-Hsien Hsu2,6, Cheng-Yu Chen2, Guo-Shu Huang2

1Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan; 2Department of Radiology, Tri-Service General Hospital, Taipei, Taiwan; 3Applied Science Laboratory, GE Healthcare, Taipei, China; 4Department of Nuclear Medicine, Tri-Service General Hospital, Taipei, Taiwan; 5EMBA in Global Chinese Management, Tamkang University, Taiwan; 6Quanta Computer Inc., Taipei

The effects of fat saturation on quantitative perfusion measurements using dynamic contrast-enhanced (DCE) MRI have not been documented for the parotid glands. In this study we included phantom and in vivo studies to compare the relationship between fat content and the difference between perfusion parameters derived from non-fat-saturated (NFS) and fat-saturated (FS) DCE-MRI. Significant differences were found for all amplitude-related parameters in parotid glands but not for muscular tissue. It is suggested that the use of FS or NFS should be explicitly specified for objective comparison of perfusion parameters with DCE-MRI on fat-containing tissues such as the parotid glands.