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Abstract #1735

Dual-Injection of a Low- And a Macro-Molecular-Weight-Contrast Media to Monitor the Blood-Brain Barrier Status in a Glioma Model Under Therapy

Benjamin Lemasson1,2, Raphal Serduc3, Cecile Maisin1,4, Audrey Bouchet3, Nicolas Coquery1,4, Philippe Robert5, Christopoh Segebarth1,4, Graldine Le Duc3, Irne Tropres1,4, Chantal Rmy1,4, Emmanuel Louis Barbier1,4

1Inersm U836, Grenoble, France; 2Oncodesign Biotechnology, Dijon, France; 3ESRF, Grenoble, France; 4Universit Joseph Fourier, Grenoble Institut des Neurosciences, Grenoble, France; 5Guerbet Research, Aulnay-Sous-Bois, France

Numerous anti-tumor therapies modify the permeability (increase or decrease) of tumoral or healthy vessels. Permeability can be assessed by Dynamic Contrast-Enhanced-MRI (DCE-MRI). Low- (0.5kDa) and macro (3.5kDa) -molecular-weight-CM, DCE-MRI was performed within the same imaging session on 80 rats bearing 9L gliosarcoma before and three times after treatments onset (antiangiogenic and/or synchrotron radiotherapy), searching for possible increase or decrease in vessel wall permeability. This study suggests that the choice of CM for a DCE-MRI depends on the physiological questions to be addressed. It also suggests that the use of two CM within the same MRI session is feasible.