Improving the Spatial Resolution of 3D GRASE ASL

Emma Louise Hall¹, Penny A. Gowland¹, Susan T. Francis¹

3D-GRASE has been used with ASL but generally at coarse in-plane resolution to reduce off-resonance phase errors, and limited slice resolution to reduce through slice decay and blurring. Here we assess the use of parallel imaging combined with multi-shot acquisition and outer volume suppression (OVS) to reduce the inter-RF spacing in 3D-GRASE, allowing the acquisition of 3D-GRASE ASL data with improved spatial resolution at 3T. OVS 3D-GRASE is applied to a functional paradigm to study visual activity.