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Abstract #1750

Towards an Optimal Distribution of B-Values for IVIM Imaging

Andreas Lemke1, Frederik Bernd Laun2, Lothar Rudi Schad1, Bram Stieltjes3

1Deparmtent of Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany; 2Department of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany; 3Deparmtent of Radiology, German Cancer Research Center, Heidelberg, Germany

The b-value distribution for IVIM imaging was optimized using Monte Carlo simulations in order to minimize the uncertainty of the biexponential fit. For three different parameter settings, illustrating the IVIM parameters in brain, liver and kidney, the error of the calculated optimal b-value distribution was compared with the error of previously reported distributions. The error for this optimized distribution was significantly lower for all parameter settings when compared with currently used distributions. The results demonstrate that the presented choice of b-values can substantially minimize the overall measurement error in IVIM and may aid the choice of b-values in clinical experiments.