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Abstract #1753

Inter- And Intra-Subject Variability of CBF Measurements Using PCASL Method

Tie-Qiang Li1, Tomas Jonsson1, Maria Kristoffersen Wiberg2, Jiongjiong Wang3

1Department of Medical Physics, Karolinska University Hospital, S-141 86, Stockholm, Sweden; 2Department of Radiology, Karolinska University Hospital, S-141 86, Stockholm, Sweden; 3Department of Radiology, University of Pennsylvania, United States

PCASL techniques have become very attractive for pharmacokinetics studies and clinical applications where repetitive, longitudinal, and quantitative CBF measurements are desirable. One important issue need to addressed is the inter- and intra-subject variability of the measured CBF results. In this study, we experimentally investigated this issue using an optimized PCASL protocol at 3T. The results indicate that the inter-subject variability is about 2-3 time of that for intra-subject depending the chosen ROI size (from voxel to whole brain).