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Abstract #1752

Comparison of Inter-Session and Intra-Session Cerebral Perfusion and Arrival Time Reproducibility on a Single Subject Using Arterial Spin Labelling.

John Robert Cain1, Gerard Thompson1, Alan Jackson1, Laura M. Parkes1,2

1Imaging Science, University of Manchester, Manchester, United Kingdom; 2Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom

Groups have published reproducibility studies for arterial spin labeling (ASL) cerebral blood flow (CBF) measurements. The relatively large inter-subject variation in CBF hinders direct comparison between individuals. A single healthy volunteer underwent MRI imaging on 7 separate occasions consisting of two STAR ASL acquisitions. Intra-session reproducibility was assessed using Bland-Altman analysis of grey matter perfusion and arrival time. Inter-session and intra-session perfusion values coefficient of variation (COV) were comparable, suggesting errors due to re-positioning and physiological changes are not significant. The COV of perfusion values are consistent with published results using multiple individuals and the arrival time COV is superior.