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Abstract #1758

Simultaneous CBF and BOLD Mapping of Electrical Acupoint Stimulation Induced Brain Activity

Yue Zhang1, Christopher B. Glielmi, Yin Jiang2, Jing Liu3, Ying Hao4, Xiaoying Wang3,4, Jing Fang, 1,4, Jisheng Han2, Jue Zhang, 1,4, Xiaoping Hu5

1College of Engineering, Peking University, Beijing, China; 2Neuroscience Research Institute, Peking University, Beijing, China; 3Dept.of Radiology, Peking University First Hospital, Beijing, China; 4Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China; 5Dept. of Biomedical Engineering, Georgia Institute of Technology / Emory University, Atlanta, United States

Blood oxygenation level dependent (BOLD) technique has been used to map brain activity related to electrical acupoint stimulation (EAS) in previous pain-relief studies, but introduces relatively poor reproducibility and consistencies. In this study, the dual-echo based simultaneous acquisition of cerebral blood flow (CBF) and BOLD was employed to provide the first evidence of CBF response to EAS and inter-subjects variation was compared between the two techniques. The results suggested that the sensitivity and specificity to sensory and pain-related regions were consistent with previous findings. Moreover, CBF based inter-subjectsvariation had a significant decrease than BOLD.