Abstract #1758

Simultaneous CBF and BOLD Mapping of Electrical Acupoint Stimulation Induced Brain Activity

Yue Zhang¹, Christopher B. Glielmi, Yin Jiang², Jing Liu³, Ying Hao⁴, Xiaoying Wang^3,4, Jing Fang,^1,4, Jisheng Han², Jue Zhang,^1,4, Xiaoping Hu⁵

¹College of Engineering, Peking University, Beijing, China; ²Neuroscience Research Institute, Peking University, Beijing, China; ³Dept.of Radiology, Peking University First Hospital, Beijing, China; ⁴Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China; ⁵Dept. of Biomedical Engineering, Georgia Institute of Technology / Emory University, Atlanta, United States

Blood oxygenation level dependent (BOLD) technique has been used to map brain activity related to electrical acupoint stimulation (EAS) in previous pain-relief studies, but introduces relatively poor reproducibility and consistencies. In this study, the dual-echo based simultaneous acquisition of cerebral blood flow (CBF) and BOLD was employed to provide the first evidence of CBF response to EAS and inter-subjects variation was compared between the two techniques. The results suggested that the sensitivity and specificity to sensory and pain-related regions were consistent with previous findings. Moreover, CBF based inter-subjectsvariation had a significant decrease than BOLD.