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Abstract #1759

Reproducibility of Arterial Spin Labeling and Blood-Oxygen Level Dependent Measures of Cerebrovascular Reactivity Using a Controlled Cerebrovascular Challenge

Jeff D. Winter1, Jackie Leung1, Manohar Shroff2,3, Andrea Kassner1,3

1Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada; 2Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada; 3Medical Imaging, University of Toronto, Toronto, Ontario, Canada

Cerebrovascular reactivity (CVR) measures of the cerebral blood flow (CBF) response to CO2 may benefit clinical assessment of cerebrovascular disease. CVR imaging is typically performed using indirect BOLD signal changes or arterial spin labeling (ASL) CBF measures. In this study, we compared between-day reproducibility of BOLD and ASL (Look-Locker acquisition) CVR measures performed with controlled CO2 transitions in adults. Reproducibility was quantified with the between-day coefficient of variation (CV). Reproducibility of ASL-CVR measures of CBF the response to CO2 (CV < 17%) were similar to BOLD-CVR (CV < 19%), which points to the potential clinical utility of this method.