Jeff D. Winter1, Jackie Leung1,
Manohar Shroff2,3, Andrea Kassner1,3
1Physiology and Experimental Medicine,
The Hospital for Sick Children, Toronto, Ontario, Canada; 2Diagnostic
Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada; 3Medical
Imaging, University of Toronto, Toronto, Ontario, Canada
Cerebrovascular
reactivity (CVR) measures of the cerebral blood flow (CBF) response to CO2
may benefit clinical assessment of cerebrovascular disease. CVR imaging is
typically performed using indirect BOLD signal changes or arterial spin
labeling (ASL) CBF measures. In this study, we compared between-day
reproducibility of BOLD and ASL (Look-Locker acquisition) CVR measures
performed with controlled CO2 transitions in adults.
Reproducibility was quantified with the between-day coefficient of variation
(CV). Reproducibility of ASL-CVR measures of CBF the response to CO2
(CV < 17%) were similar to BOLD-CVR (CV < 19%), which points to the
potential clinical utility of this method.