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Abstract #1762

Dynamic Changes in Blood Transit Time and Flow During Somatosensory Stimulation Measured by Dynamic ASL with High Temporal Resolution

Yuguang Meng1, Seong-Gi Kim1,2

1Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States; 2Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, United States

The blood transit time from arterial spin labeling plane to capillaries in the imaging slice (referred to as tissue transit time) decreased during neuronal activation in humans, while it appeared no changes during somatosensory stimulation in rats. Since a tissue transit time is shorter in rats compared to humans, shortening blood transit time may not be detectable with arterial spin labeling (ASL) data with low temporal resolution. Thus, it is important to carefully measure dynamic transit time changes during stimulation. In this work, the dynamics of both CBF and the blood transit time during rat forepaw stimulation were simultaneously measured with a modified dynamic ASL (DASL) method with improved temporal resolution.