Johanna Kramme1,2, Johannes Gregori1,2,
Matthias Gnther2,3
1Division of Neurology, University
Hospital Mannheim of the University of Heidelberg, Mannheim, Germany; 2Fraunhofer
MEVIS-Institute for Medical Image Computing, Bremen, Germany; 3Faculty
for Physics and Electrical Engineering, University Bremen, Bremen, Germany
To
increase sensitivity and reduce physiological noise in ASL T2 measurements a
single shot 3D-GRASE approach was developed. Compared to sequential
acquisition of the different echo times significant reduction in scan time
and physiological noise can be achieved. To improve T2 calculations the
inflow time TI of each data set has to be corrected for each echo time. Based
on the TE correction of TI the reliability of the T2 estimate could be
improved by a factor of two and more. With these improvements ASL T2
measurements become feasible in a clinical stetting.