Lirong Yan1, Yan Zhuo1, Jing An2, Jiongjiong Wang3
1Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; 2Siemens Mindit Magnetic Resonance, Siemens Healthcare, MR Collaboration NE Asia, Shenzhen, China; 3Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States
In the present study, we present a novel technique termed TrueFISP based Spin Tagging with Alternating Radiofrequency (TrueSTAR) for both time-resolved 4-D MR angiography (MRA) and dynamic microvascular flow (perfusion) imaging. We demonstrate that TrueSTAR is able to delineate the dynamic filling of cerebrovasculature with a spatial resolution of 1x1x1mm3 and a temporal resolution of 50ms. Dynamic microvascular flow imaging using TrueSTAR is able to follow hemodynamic changes during visual cortex activation every 85ms.