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Abstract #1783

Dynamic Susceptibility Contrast Imaging Using a Multi-Echo Spiral Sequence

Nicolas Pannetier1,2, Thomas Christen1,2, Mohamed Tachrount1,2, Benjamin Lemasson1,3, Regine Farion1,2, Sebastien Reyt1,2, Nicolas Coquery1, Christoph Segebarth1,2, Chantal Remy1,2, Emmanuel Louis Barbier1,2

1Inserm, U836, Grenoble, France; 2Universit Joseph Fourier, Grenoble Institut des Neurosciences, UMR-S836, Grenoble, France; 3Oncodesign Biotechnology, Dijon, France

To characterize microvasculature, one can perform a DCE-MRI followed by a DSC-MRI experiment. However, estimates from a DSC experiment performed after a DCE-MRI experiment differ from estimates derived from a single DSC experiment, especially due to different T1. In this study, we investigate how T1 effect contributes to rCBV estimates in the case of one and two consecutive injections of contrast agent (CA). Thus, we used a multi echo spiral sequence in a rat glioma model. Results suggest that DSC-MRI performed during a second injection of CA is less sensitive to T1 effects than DSC-MRI performed during a first injection.