Emelie
Lindgren1, Linda Knutsson1, Danielle van Westen2,3,
Karin Markenroth Bloch4, Freddy Sthlberg1,3, Ronnie
Wirestam1
1Department of Medical Radiation
Physics, Lund University, Lund, Sweden; 2Center for Medical
Imaging and Physiology, Lund University Hospital, Lund, Sweden; 3Department
of Diagnostic Radiology, Lund University, Lund, Sweden; 4Philips
Medical Systems, Lund, Sweden
The
phase shift during a contrast-agent bolus passage is assumed to be
proportional to the concentration of contrast agent. In this study,
phase-shift curves in tissue and artery were registered and a phase-based
perfusion index and grey-matter MTT were calculated. The relationship between
the phase-based perfusion index and ASL CBF estimates showed good linear
correlation (r=0.81). The mean grey-matter MTT was 5.4 s, consistent with
literature values. Phase-based absolute quantification of CBF is difficult,
but the use of a phase-based perfusion index for rescaling of DSC-MRI results
can potentially be of value to achieve more robust and reproducible DSC-MRI
estimates.
Keywords