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Abstract #1786

Effects of Blood δR2* Non-Linearity on Absolute Perfusion Quantification Using DSC-MRI: Comparison with Xe-133 SPECT

Linda Knutsson1, Freddy Sthlberg1,2, Ronnie Wirestam1, Matthias Johannes Paulus van Osch3

1Department of Medical Radiation Physics, Lund University, Lund, Sweden; 2Department of Diagnostic Radiology, Lund University, Lund, Sweden; 3Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

A linear relationship between the δR2* and contrast agent concentration in blood is often assumed, however, calibration measurements in whole blood have shown that a non-linear relation between δR2* and contrast agent concentration exists. In this evaluation of CBF data, we compared absolute CBF obtained using DSC-MRI and Xe-133 SPECT, using both a linear relationship and a non-linear relationship when applying a venous output function (VOF) correction scheme to DSC-MRI data from healthy subjects. The results showed that the observed degrees of correlation were similar when the linear and non-linear relationships were applied to the AIF and VOF from DSC-MRI.