Linda Knutsson1, Freddy Sthlberg1,2,
Ronnie Wirestam1, Matthias Johannes Paulus van Osch3
1Department of Medical Radiation
Physics, Lund University, Lund, Sweden; 2Department of Diagnostic
Radiology, Lund University, Lund, Sweden; 3Department of
Radiology, Leiden University Medical Center, Leiden, Netherlands
A
linear relationship between the δR2* and contrast agent concentration in
blood is often assumed, however, calibration measurements in whole blood have
shown that a non-linear relation between δR2* and contrast agent
concentration exists. In this evaluation of CBF data, we compared absolute
CBF obtained using DSC-MRI and Xe-133 SPECT, using both a linear relationship
and a non-linear relationship when applying a venous output function (VOF)
correction scheme to DSC-MRI data from healthy subjects. The results showed
that the observed degrees of correlation were similar when the linear and
non-linear relationships were applied to the AIF and VOF from DSC-MRI.