Matus Straka1, Gregory W. Albers2,
Roland Bammer1
1Radiology, Stanford University,
Stanford, CA, United States; 2Stroke Center, Stanford University
Medical Center, Stanford, CA, United States
Two
widely used methods exist for computing cerebral blood volume (CBV) in
DSC-MRI perfusion, using measured signals as well as deconvolved residue
function. Some authors claim that these methods do not deliver identical
results. We explain that the methods must deliver equivalent results and any
difference in obtained values is just caused by signal post-processing errors
and wrong interpretation of indicator-dilution theory and convolution
theorem. Identity of the two methods is shown in time- and frequency-domains
as well as by means of numerical results. Possible sources of the processing
errors are discussed and solutions how to avoid those are proposed.