Equivalence of CBV Measurement Methods in DSC-MRI

Matus Straka¹, Gregory W. Albers², Roland Bammer¹

Two widely used methods exist for computing cerebral blood volume (CBV) in DSC-MRI perfusion, using measured signals as well as deconvolved residue function. Some authors claim that these methods do not deliver identical results. We explain that the methods must deliver equivalent results and any difference in obtained values is just caused by signal post-processing errors and wrong interpretation of indicator-dilution theory and convolution theorem. Identity of the two methods is shown in time- and frequency-domains as well as by means of numerical results. Possible sources of the processing errors are discussed and solutions how to avoid those are proposed.