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Abstract #1794

Design of a Data Driven Deconvolution Filter for DSC Perfusion

Philipp Emerich1, Peter Gall1, Birgitte Fuglsang Kjlby2, Elias Kellner1, Irina Mader3, Valerij Kiselev1

1Medical Physics, University Hospital Freiburg, Freiburg, Germany; 2Dept. of Neuroradiology, Arhus University Hospital, Arhus, Denmark; 3Dept. of Neuroradiology, University Hospital Freiburg, Freiburg, Germany

Bolus tracking perfusion evaluation relies on the deconvolution of a tracer concentration time-courses in an arterial and a tissue voxel following the tracer kinetic model. The object of this work is to propose a method to design a data driven Tikhonov regularization filter in the Fourier domain and to compare it to the singular value decomposition (SVD) based approaches using the mathematical equivalence of Fourier and circular SVD (oSVD).