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Abstract #1796

MR-Guided Focused Ultrasound Ablation of the Rat Liver

Randy Lee King1,2, Viola Rieke1, Kim Butts Pauly1

1Department of Radiology, Stanford University, Stanford, CA, United States; 2Department of Bioengineering, Stanford University, Stanford, CA, United States

This study investigates the use of a rat model for the MR-guided focused ultrasound treatment of hepatocellular carcinoma. PRF-thermometry, thermal dose calculation and post-ablation imaging are used to determine the ablated liver area and compared to necropsy. Thermal dose reliably predicts the ablated area for single sonications, but care has to be taken to avoid overestimation in lesions resulting from multiple sonications.