Abstract #1797

Non-Invasive Suppression of Animal-Model Chronic Epilepsy Using Image-Guided Focused Ultrasound

Seung-Schik Yoo¹, KwangIk Jung¹, YongZhi Zhang¹, Nathan McDannold¹, Alexander Bystritsky,¹², Ferenc A. Jolesz¹

¹Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States; ²Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States

We showed the evidence of MRI-guided focused ultrasound can suppress the ictal actvity induced by the chemical kindling of rat brain via kainic acid. This evidence demonstrate that non-invasive suppression of epilepsy may be feasible using pulsed, low-energy focused ultrasound.