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Abstract #1806

Temperature Sensitive Liposomes for Drug Delivery with MRI-HIFU

Mariska de Smet1, Sander Langereis2, Roland van de Molengraaf2, Edwin Heijman2, Nicole Hijnen1, Holger Gruell1,2

1Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands; 2Biomolecular Engineering, Philips Research Eindhoven, Eindhoven, Netherlands

Temperature sensitive liposomes (TSL) incorporating both a chemotherapeutic drug, i.e. doxorubicin, and a clinically approved MRI contrast agent, [Gd(HPDO3A)(H2O)] were prepared and evaluated for MR image guided drug delivery. A gel phantom was prepared containing spots of agarose gel mixed with the liposomes. Before and after heating with High Intensity Focused Ultrasound (HIFU), a T1 map was obtained with a Look-Locker EPI-sequence. When heated above the phase transition temperature, the TSLs showed a rapid release of both the drug and contrast agent. The spots with liposomes which were heated with HIFU clearly showed a lower T1 after ultrasound application.