Hsu-Hsia Peng1, Teng-Yi Huang2, Hsiao-Wen Chung3, Shiun-Ying Ju2, Yao-Hao Yang2, Po-Cheng Chen4, Yu-Hui Ding4, Wen-Shiang Chen4, Wen-Yih Isaac Tseng5
1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan; 2Department of Electrical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan; 3Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan; 4Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan; 5Center for Optoelectronic Biomedicine, Medical College of National Taiwan University, Taipei, Taiwan
In this study, an imaging sequence, which simultaneously monitors temperature change and magnetization transfer (MT) contrast at 2-sec temporal resolution, was applied on rabbit thigh muscle during HIFU sonicaiton to verify in vivo feasibility. The characteristics of better immunity to phase variance (in contrast to temperature mapping derived from phase images) and clear distinction between heated spot (4.29%0.41%) and non-heated region (-0.19%0.30%) of MT, even after turning off HIFU pulse, suggest its usefulness in long-term monitoring. In conclusion, MRI with simultaneous temperature and MT mapping is an effective technique to evaluate tissue damage for HIFU treatment.