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Abstract #1813

A High Precision MR-Compatible Positioning System for Focused Ultrasound Experiments in Small Animal Models

Adam Christian Waspe1,2, Anthony Chau1, Rajiv Chopra1,2, Kullervo Hynynen1,2

1Imaging Research Discipline, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; 2Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

An MR-compatible system was developed for performing focused-ultrasound exposures in preclinical models. A focused-ultrasound transducer attaches to the positioning system and is submerged within a closed water tank. Sonicating a phantom and measuring the thermal focal zone registers ultrasound and MRI coordinates. For each axis, a 5 cm travel and 0.1 mm positioning resolution was achieved. The system was constructed with non-magnetic components and operation of the focused-ultrasound system within the bore during imaging did not result in any mutual interference. This system is used to study the applications of ultrasound energy for novel therapeutic applications in preclinical animal models.