Cory Robert Wyatt1, Brian J. Soher2, Kavitha Arunachalam3, James R. MacFall2
1Department of Biomedical Engineering, Duke University, Durham, NC, United States; 2Department of Radiology, Duke University Medical Center, Durham, NC, United States; 3Department of Radiation Oncology, Duke University Medical Center, Durham, NC, United States
Multi-echo fat-water fitting techniques that separate the fat and water effects have been shown to be useful in measuring temperature in fat-water phantoms. In this study we explore optimization of echo time selection by minimizing the temperature noise using Cramer-Rao Lower Bound (CRLB) analysis. Accuracy of fitting is improved by including multiple fat peaks and T2* effects. Our approach finds the minimum temperature noise that has the minimum sensitivity to the values of nominally fixed parameters. The CRLB results were then confirmed in experiments with fat-water gelatin phantoms.