Cory Robert Wyatt1, Brian J. Soher2,
Kavitha Arunachalam3, James R. MacFall2
1Department of Biomedical Engineering,
Duke University, Durham, NC, United States; 2Department of
Radiology, Duke University Medical Center, Durham, NC, United States; 3Department
of Radiation Oncology, Duke University Medical Center, Durham, NC, United
States
Multi-echo
fat-water fitting techniques that separate the fat and water effects have
been shown to be useful in measuring
temperature in fat-water phantoms. In
this study we explore optimization of echo time selection by minimizing the
temperature noise using Cramer-Rao Lower Bound (CRLB) analysis. Accuracy of fitting is improved by
including multiple fat peaks and T2* effects. Our approach finds the minimum
temperature noise that has the minimum sensitivity to the values of nominally
fixed parameters. The CRLB results
were then confirmed in experiments with fat-water gelatin phantoms.
Keywords