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Abstract #1822

Measurement of Human Brain Temperature Changes During Cooling

Jan Weis1, Lucian Covaciu2, Sten Rubertsson2, Mats Allers3, Anders Lunderquist4, Francisco Ortiz-Nieto1, Hkan Ahlstrm1

1Department of Radiology, University Hospital, Uppsala, Sweden; 2Department of Surgical Sciences, Anesthesiology and Intensive Care, University Hospital, Uppsala, Sweden; 3Department of Clinical Sciencies, University Hospital, Lund, Sweden; 4Department of Clinical Sciences, University Hospital, Lund, Sweden

Decrease of the human brain temperature (1-2 oC in 15 minutes) was induced by intranasal cooling. The purpose of this study was to verify the cooling technique on the volunteers and to compare two methods for noninvasive monitoring of the relative brain temperature: MRSI with high spatial and reduced spectral resolution and PRF shift technique. Ability of the proposed brain cooling technique to induce moderate hypothermia was confirmed. Good agreement was found between relative temperatures measured by MRSI and PRF method. Both temperature mapping techniques can be used for monitoring the brain temperature changes during hypothermia.