Alastair Martin1, Mark Richardson2,
1Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, CA, United States; 2Neurological Surgery, University of California - San Francisco; 3SurgiVision, Inc, Irvine, CA
A novel delivery system for MR guided precision minimally invasive access to deep brain structures is presented. A targeting accuracy of 0.5 mm at depths of 85-90mm is achieved in a phantom model. The delivery system is also used to insert cannulas for infusing therapeutic agents via convection-enhanced delivery (CED). CED is demonstrated in a non-human primate with infusions to the thalamus, putamen and sub-thalamic nucleus. Accurate delivery of infusion cannulas was achieved and CED infusions extending up to 10mm in diameter are demonstrated.