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Abstract #1837

Novel Delivery System for Minimally Invasive MR Guided Neurological Interventions

Alastair Martin1, Mark Richardson2, Adrian Kells2, John Bringas2, Pete Piferi3, Lisa Tansey3, Geoffrey Bates3, Philip Starr2, Paul Larson2, Krystof Bankiewicz2

1Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, CA, United States; 2Neurological Surgery, University of California - San Francisco; 3SurgiVision, Inc, Irvine, CA

A novel delivery system for MR guided precision minimally invasive access to deep brain structures is presented. A targeting accuracy of 0.5 mm at depths of 85-90mm is achieved in a phantom model. The delivery system is also used to insert cannulas for infusing therapeutic agents via convection-enhanced delivery (CED). CED is demonstrated in a non-human primate with infusions to the thalamus, putamen and sub-thalamic nucleus. Accurate delivery of infusion cannulas was achieved and CED infusions extending up to 10mm in diameter are demonstrated.