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Abstract #1862

Targeted Magnetic Delivery of Cells with an MRI Scanner

Johannes Riegler1,2, Jack A. Wells1, Panagiotis Kyrtatos1, Anthony N. Price1, Mark F. Lythgoe1

1Centre for Advanced Biomedical Imaging (CABI), Department of Medicine and Institute of Child Health, University College London (UCL), London, United Kingdom; 2Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), UCL, London, United Kingdom

Targeted delivery of cells or drugs is a technique that could increase the efficacy of medical treatments. One possibility for that is using magnetic fields to drag labelled entities to the site of interest. MRI systems are particular interesing for this purpose due to their ability to generate uniform magnetic field gradients across the whole body. We demonstrated the feasibility of steering magnetically labelled cells to one exit tube of a bifurcation phantom by applying MR imaging gradients. This technique could potentially be used for localised cell delivery in the vascular system.