1Department of Neurosurgery, Mayo Clinic, Rochester, MN, United States; 2Department of Radiology, Mayo Clinic, Rochester, MN, United States; 3Department of Engineering, Mayo Clinic, Rochester, MN, United States; 4Department of Psychology, University of Memphis; 5Biological Sciences, Illinois State University
Electroanalytical techniques such as fast-scan cyclic votlammetry (FSCV) and constant-potential amperometry (CPA) have revolutionized neuroscience research by supporting temporally, spatially, and chemically resolved neurotransmitter measurements in the brain. CPA and FSCV were performed by a small, digital-telemetry device called a wireless instantaneous neurotransmitter concentration system (WINCS) specifically developed for neurochemical monitoring. Test measurements were collected during simultaneous 3T imaging using a fast spin echo sequence. WINCS dynamically recorded dopamine electrochemical signatures with sub-second temporal resolution and with high fidelity. We demonstrate proof-of-concept for combining WINCS real-time neurochemical measurements and 3T MRI that may offer simultaneous neurochemical monitoring during fMRI.