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Abstract #1863

Simultaneous Wireless Fast Scan Cyclic Voltammetry and Amperometry with 3T MRI

Kendall Lee1, Jonathan Bledsoe1, Kiaran McGee2, John Huston2, Chris Kimble3, Filippo Agnesi, Kevin Bennet3, Charles Blaha4, Paul Garris5

1Department of Neurosurgery, Mayo Clinic, Rochester, MN, United States; 2Department of Radiology, Mayo Clinic, Rochester, MN, United States; 3Department of Engineering, Mayo Clinic, Rochester, MN, United States; 4Department of Psychology, University of Memphis; 5Biological Sciences, Illinois State University

Electroanalytical techniques such as fast-scan cyclic votlammetry (FSCV) and constant-potential amperometry (CPA) have revolutionized neuroscience research by supporting temporally, spatially, and chemically resolved neurotransmitter measurements in the brain. CPA and FSCV were performed by a small, digital-telemetry device called a wireless instantaneous neurotransmitter concentration system (WINCS) specifically developed for neurochemical monitoring. Test measurements were collected during simultaneous 3T imaging using a fast spin echo sequence. WINCS dynamically recorded dopamine electrochemical signatures with sub-second temporal resolution and with high fidelity. We demonstrate proof-of-concept for combining WINCS real-time neurochemical measurements and 3T MRI that may offer simultaneous neurochemical monitoring during fMRI.