T. Kevin Hitchens1,2, Parker H. Mills1,2,
Lesley M. Foley1, John A. Melick3, Patrick M. Kochanek3,4,
Eric T. Ahrens1,2, Chien Ho1,2
1Pittsburgh NMR Center for Biomedical
Research, Carnegie Mellon University, Pittsburgh, PA, United States; 2Department
of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, United
States; 3Safar Center for Resuscitation Research, University of
Pittsburgh, Pittsburgh, PA, United States; 4Department of Critical
Care Medicine and Anesthesiology, University of Pittsburgh, Pittsburgh, PA,
United States
Cellular
imaging is an important and growing field in magnetic resonance. The ability
to non-invasively detect the trafficking and accumulation of cells in vivo has
broad implications for both a better understanding of biological processes
and the development of novel treatments for numerous conditions. Here explore
using post processing techniques called Phase map cross-correlation Detection
and Quantification or PDQ for detection and quantification of single
MPIO-labeled cells in vivo. PDQ uses phase information to calculate a
magnetic dipole moment for each detected cell. This information can be used to correlate
labeled cell between serial scans and imaging methods.
Keywords