Abstract #1877
Customizable
PLGA-Encapsulated Perfluorocarbon Particles for in Vivo 19F MRI
Mangala
Srinivas1, Fernando Bonetto1, Luis Javier Cruz1,
Arend Heerschap2, Carl Figdor1, I. J.M. de Vries1
1Tumor
Immunology, NCMLS, Uni. Radboud, Nijmegen,
Gelderland, Netherlands;
2Radiology, Nijmegen
Centre for Molecular Life Sciences
We
present a novel agent for in vivo 19F
MRI that is customizable in
several parameters including diameter, lifetime, fluorocarbon content,
particle charge and coating. The particles can also be covalently bound to
targeting agents, dyes, drugs or other moieties, and are stable for long-term
storage. We test the particles for labeling primary human dendritic cells for
use in cell-based vaccine therapy. The particles can be adapted for use in
various experimental systems, as well as clinical use.
