Praveen
Kumar Gulaka1, Vikram D. Kodibagkar1,2
1Biomedical Engineering, UT Arlington
and UT Southwestern Medical Center at Dallas, Dallas, Tx, United States; 2Radiology,
UT Southwestern Medical Center at Dallas, Dallas, Tx, United States
The
ability to measure tissue oxygen tension non-invasively may have a
significant impact in understanding mechanisms of tissue function and in
clinical prognosis of disease. Previous research demonstrated
hexamethyldisiloxane (HMDSO) as a 1H based pO2 reporter molecule by in vivo
spectroscopy and imaging using Proton
Imaging of Siloxanes to map Tissue Oxygenation Levels (PISTOL)
technique. We now present in vitro
data demonstrating the pO2 calibration curves of linear and cyclic siloxanes
of different chain lengths as pO2 sensing reporter molecules for use in
conjunction with PISTOL.
Keywords