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Abstract #1907

Mn-Loaded Apoferritin: A High Sensitivity, Biologically Compatible MRI Agent.

Simonetta Geninatti-Crich1, Ferenc Kalman1, Ibolya Szabo1, Stefania Lanzardo1, Juan Carlos Cutrin1, Laura Conti1, Silvio Aime1

1University of Torino, Torino, Italy

An innovative approach to the design of MRI Contrast Agents has been pursued through the entrapment of Mn(II) aqua ions inside the inner cavity of Apoferritin. This imaging probe can be proposed in the diagnosis of a variety of liver diseases involving an alteration in the hepatic iron storing capabilities (e.g. hepatocellular carcinoma, fibrosis, cirrhosis).