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Abstract #1908

[Gd(Try-TTDA)] 2-: Magnetic Resonance Based Sensor for the Specific Detection of Cu2+ in Living Cells

Gin-Chung Liu1,2, Dayananda Kasala3, Tsung-Sheng Lin3, Chiao-Yun Chen1,4, Twei-Shiun Jaw1,2, Yu-Ting Kuo1,2, Yun-Ming Wang3

1Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 2Department of Radiology,Faculty of Medicine,College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 3Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan; 4Department of Radiology,Faculty of Medicine,College of Medicine, Kaohsiung Medical University, Kaohsiung , Taiwan


In this study, we have developed a new contrast agent [Gd(Try-TTDA)] 2- that can recognize Cu2+ ion in the living cells. In addition, the Gd3+ complex attributes excellent selectivity for Cu2+ over a choice of other metal ions. A gradual increases in the relaxivity and signal intensity of ex vitro and in vitro MR imaging upon Cu2+ detection. These results implicate that a new MR based contrast agent [Gd(Try-TTDA)])] 2- can serve as a Cu2+ sensor using relaxometry and MR imaging

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