Gin-Chung Liu1,2, Dayananda Kasala3,
Tsung-Sheng Lin3, Chiao-Yun Chen1,4, Twei-Shiun Jaw1,2,
Yu-Ting Kuo1,2, Yun-Ming Wang3
1Department of Medical Imaging,
Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 2Department
of Radiology,Faculty of Medicine,College of Medicine, Kaohsiung Medical
University, Kaohsiung, Taiwan; 3Department of Biological Science
and Technology, National Chiao Tung University, Hsinchu, Taiwan; 4Department
of Radiology,Faculty of Medicine,College of Medicine, Kaohsiung Medical
University, Kaohsiung , Taiwan
In
this study, we have developed a new contrast agent [Gd(Try-TTDA)] 2-
that can recognize Cu2+ ion in the living cells. In addition, the Gd3+ complex
attributes excellent selectivity for Cu2+ over a choice of other
metal ions. A gradual increases in the relaxivity and signal intensity of ex
vitro and in vitro MR imaging upon Cu2+ detection. These results
implicate that a new MR based contrast agent [Gd(Try-TTDA)])] 2-
can serve as a Cu2+ sensor using relaxometry and MR imaging
Keywords