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Abstract #1909

In Vivo quantification of SPIO Nanoparticles with Phase Gradient Mapping

Jason A. Langley1, E Kay Jordan2, Wei Liu3, Joseph A. Frank2, Qun Zhao1

1Department of Physics and Astronomy, The University of Georgia, Athens, GA, United States; 2Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, MD, United States; 3Phillips Research, North America, Briarcliff Manor, NY, United States

A method for quantifying concentrations of SPIO nanoparticles is presented in this abstract and the proposed method is tested on SPIO-labeled tumors that were implanted in the flank of nude mice. Each voxel within the tumor was modeled as a homogeneous sphere with magnetization m. The magnetic field gradient from each voxel was then superimposed to form the theoretical magnetic field gradient of the tumor, which was then fitted to the gradient of the experimental field map, measured by the acquired phase maps. The results from the x-component of the phase gradient accord well with the known SPIO concentrations.