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Abstract #1910

Study of Gd-Based MR Contrast Agents Encapsulated in the Phosphatidylglyceroglycerol-Based Thermosensitive Liposomes for Improved MR-Guided Chemothermotherapy

Tungte Wang1,2, Martin Hossann1,2, Michael Peller3, Maximilian Reiser3, Rolf Dieter Issels1,2, Lars Hans Lindner1,2

1Department of Internal Medicine III, University Hospital, Grosshadern, Munich, Bavaria, Germany; 2CCG Hyperthermia, Institute of Molecular Immunology, Helmholtz Center Munich German Research Center for Environmental Health, Munich, Bavaria, Germany; 3Department of Clinical Radiology, University Hospital, Grosshadern, Munich, Bavaria, Germany

Phosphatidylglyceroglycerol (DPPGOG)-based thermosensitive liposomes (TSL) with encapsulated proton MR Gd-based T1 contrast agent (CA) have been proposed for noninvasive MR thermometry during tumor treatment using chemothermotherapy. In this work, the DPPGOG-TSL with four separately encapsulated Gd-based CAs which have diverse chemical structures were studied in vitro by measuring the temperature dependence of their T1 while heated from 30 to 50 C. The measurements revealed that the release of macrocyclic nonionic Gd-based CA from the DPPGOG-TSL resulted in the most percent T1 decrease and thus the DPPGOG-TSL with such encapsulated CA has the potential for the optimal T1 enhancement effect.