Tungte Wang1,2,
Martin Hossann1,2, Michael Peller3, Maximilian Reiser3,
Rolf Dieter Issels1,2, Lars Hans Lindner1,2
1Department of Internal Medicine III,
University Hospital, Grosshadern, Munich, Bavaria, Germany; 2CCG
Hyperthermia, Institute of Molecular Immunology, Helmholtz Center Munich
German Research Center for Environmental Health, Munich, Bavaria, Germany; 3Department
of Clinical Radiology, University Hospital, Grosshadern, Munich, Bavaria,
Germany
Phosphatidylglyceroglycerol
(DPPGOG)-based thermosensitive liposomes (TSL) with encapsulated proton MR
Gd-based T1 contrast agent (CA) have been proposed for noninvasive MR
thermometry during tumor treatment using chemothermotherapy. In this work,
the DPPGOG-TSL with four separately encapsulated Gd-based CAs which have
diverse chemical structures were studied in vitro by measuring the temperature
dependence of their T1 while heated from 30 to 50 C. The measurements
revealed that the release of macrocyclic nonionic Gd-based CA from the
DPPGOG-TSL resulted in the most percent T1 decrease and thus the DPPGOG-TSL
with such encapsulated CA has the potential for the optimal T1 enhancement
effect.
Keywords