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Abstract #1911

Porous Mn2+ - Fe3O4 Nanoparticles with High T1 and T2 Relaxivity

Veronica Clavijo Jordan1, Michael R. Caplan1, Kevin M. Bennett1

1Bioengineering, Arizona State University, Tempe, AZ, United States

We report a protein based nanoparticle with a Fe3O4 crystal core and Mn2+ bound to surface channels. The metal core size ranged from 3 to 6nm in diameter, and ICP results indicate 7 Mn2+ per protein. HRTEM shows that the core metal is magnetite with a lattice spacing of 0.25nm. Following the proposed synthesis, we suspect that the high per-ion T1 (338mM-1s-1) and T2 (133 mM-1s-1) relaxivity are due to a cooperative effect contributed by the Mn2+ and the Fe3O4 crystal. MRI scans of rat brain inoculations show it can be detected in vivo.