Ying-Hsiu Lin1, Gin-Chung Liu2,3,
Twei-Shiun Jaw2,3, Yu-Ting Kuo2,3, Chiao-Yun Chen2,3,
Yun-Ming Wang1
1Department of Biological Science and
Technology, National Chiao Tung University, Hsinchu, Taiwan; 2Department
of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;
3Department of Radiology,Faculty of Medicine,College of Medicine,
Kaohsiung Medical University, Kaohsiung, Taiwan
This
study describes the synthesis and biologic evaluation of a IL11 peptide
targeted dual-labeled imaging agent as a potential probe for detecting human
breast cancer. The IL11 peptide substrate was synthesized and conjugated with
the TTDA chelating moiety and cy5.5 via solid-phase peptide synthesis. The
results of in vitro optical and MR imaging indicated that the targeted
contrast agent specifically targeted to human breast cancer cell and lead to
significant enhancement. The preliminary results also demonstrated that the
bimodal IL-11 peptide analog could be used to detect IL-11Rα positive
breast cancer with MRI and fluorescence microscope at the cellular level.
Keywords