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Abstract #1915

A Peptide Based Dual-Labeled Agent Targeted to Interleukin 11 Receptor Alpha-Chain for Molecular Imaging

Ying-Hsiu Lin1, Gin-Chung Liu2,3, Twei-Shiun Jaw2,3, Yu-Ting Kuo2,3, Chiao-Yun Chen2,3, Yun-Ming Wang1

1Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan; 2Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 3Department of Radiology,Faculty of Medicine,College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

This study describes the synthesis and biologic evaluation of a IL11 peptide targeted dual-labeled imaging agent as a potential probe for detecting human breast cancer. The IL11 peptide substrate was synthesized and conjugated with the TTDA chelating moiety and cy5.5 via solid-phase peptide synthesis. The results of in vitro optical and MR imaging indicated that the targeted contrast agent specifically targeted to human breast cancer cell and lead to significant enhancement. The preliminary results also demonstrated that the bimodal IL-11 peptide analog could be used to detect IL-11Rα positive breast cancer with MRI and fluorescence microscope at the cellular level.