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Abstract #1916

A Dual Modality Nanoparticle MRI/CT Contrast Agent with Enhanced T1 and T2 Relaxivity

Simon A. Lubek1, Veronica Clavijo Jordan1, Kevin M. Bennett1

1Bioengineering, Arizona State University, Tempe, AZ, United States

We report a dual MRI/CT protein based W-Fe nanoparticle contrast agent with high T1 (4,497 mM-1s-1) and T2 (458,143 mM-1s-1) per particle relaxivities. The T1 relaxivities observed demonstrated a 58 fold increase over iron oxide particles. TEM results showed nanoparticles ranging from 9 to 13nm in diameter. Rat striatum MRI scans demonstrated the agent is detectable in vivo. Furthermore, a CT comparison demonstrated a 1.5 fold contrast increase as compared to iron oxide particles.