Improving T1-Weighted "Hot Spot" Imaging with Colloidal Iron Oxide Nanoparticles

Shelton D. Caruthers¹, Angana Senpan¹, Dipanjan Pan¹, Grace Hu¹, Samuel A. Wickline¹, Gregory M. Lanza¹

Iron oxide nanoparticles have been extensively used for nontargeted and targeted imaging applications based upon highly sensitive T2* imaging properties, which typically result in negative contrast effects. Colloidal Iron Oxide Nanoparticles offer both traditional T2* detection and T1 weighted "hot spot" detection. This work explores the mechanisms for improving this T1 detectability.