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Abstract #1920

Improving T1-Weighted "Hot Spot" Imaging with Colloidal Iron Oxide Nanoparticles

Shelton D. Caruthers1, Angana Senpan1, Dipanjan Pan1, Grace Hu1, Samuel A. Wickline1, Gregory M. Lanza1

1C-TRAIN, Washington University, St. Louis, MO, United States

Iron oxide nanoparticles have been extensively used for nontargeted and targeted imaging applications based upon highly sensitive T2* imaging properties, which typically result in negative contrast effects. Colloidal Iron Oxide Nanoparticles offer both traditional T2* detection and T1 weighted "hot spot" detection. This work explores the mechanisms for improving this T1 detectability.