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Abstract #1932

MR Imaging of Angiogenesis in Tumor Xenografts by α vβ 3 - Targeted Magnetofluorescent Micellar Nanoprobes

Chase W. Kessinger1, Chalermchai Khemtong1, Osamu Togao1, Masaya Takahashi1, Jinming Gao1

1UT Southwestern Medical Center, Dallas, TX, United States

Here we report the use of αvβ3- targeted magnetofluorescent micellar nanoprobes that allowed detection of angiogenic tumor vessels by both fluorescent and magnetic resonance imaging methods. The αvβ3-targeting specificity and temporal tumor accumulation profiles were demonstrated in a human lung tumor xenograft model in nude mice using 3D gradient echo sequences and T2* - weighted dynamic contrast enhancement MRI over one hour.