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Abstract #1931

Molecular Susceptibility Contrast MRI of Tumor Angiogenesis with Targeted Iron Oxide Nanoparticles

Martijn Wolters1,2, Marlies Oostendorp1,3, Bram F. Coolen2, Mark J. Post3,4, Gustav J. Strijkers2, Klaas Nicolay2, Walter H. Backes1,3

1Department of Radiology, Maastricht University Medical Center, Maastricht, Netherlands; 2Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 3Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, Netherlands; 4Department of Physiology, Maastricht University, Maastricht, Netherlands

The purpose of this study was to evaluate Susceptibility Gradient Mapping (SGM) for molecular MRI to selectively detect tumor angiogenesis in mice with cNGR-labeled SPIOs. SGM is a positive contrast technique to detect susceptibility effects of SPIOs. In this experimental study we found CNR values for SGM comparable to gradient echo (GE) images. Furthermore, a trend towards stronger contrast enhancement for targeted SPIOs compared with untargeted SPIO was perceived.